The pharmacological behavior of the urinary bladder and its vasculature of the dog.

pounds administered into the caudal vesical arteries were investigated under blood perfusion at a constant rate. TEA, physostigmine, phenylephrine, 5hydroxytryptamine, angiotensin II, lys-vasopressin, oxytocin and ergotamine caused a contraction of the bladder and constriction of the vesical vascular bed. Acetylcholine, bethanechol, carbachol, TMA, lobeline, nicotine, DMPP, neostig mine, histamine, bradykinin, eledoisin, kallikrein, ATP, KCl and morphine produced a contraction of the bladder and dilation of the vesical vascular bed. Noradrenaline, adrenaline, dopamine and tyramine caused a relaxation of the bladder and vasoconstriction. Only isoprenaline produced a, relaxation of the bladder and vasodilation. Ephedrine and methoxamine constricted the vesical vascular bed but exerted no effect on the bladder itself. Aminophylline, dipyridamole, hydralazine, nitroglycerin, papaverine, adenosine, AMP, ADP, UMP, UDP, UTP, DPN, TPN, procaine and tetrodotoxin dilated the vesical vascular bed without affecting the bladder. These results indicate that the vesical vascular bed has pharmacological characteristics of its own.